Assessment of Fluid Tissue Interaction Using Multi-Modal Image Fusion for Characterization and Progression of Coronary Atherosclerosis In medical collaboration with: Department of Cardiology, Medizinische Poliklinik der Universität München (Germany) Department of Cardiology, Faculty of Medicine, Yeditepe Üniversitesi (Turkey) Scientific Director: Prof. Dr. Nassir Navab and Assoc. Prof. Dr. Gözde Ünal, Sabanci Üniversitesi (Turkey) Contact Person(s): Dr. Stefanie Demirci

Keywords: Registration / Visualization, Segmentation, Medical Imaging, Computer-aided Interventions, Past Projects

Abstract

Coronary artery diseases such as atherosclerosis are the leading cause of death in the industrialized world. In this project, we develop computational tools for segmentation and registration problems on intravascular images including IVUS (Intravascular Ultrasound) and OCT (Optical Coherence Tomography). One sample component of this project is Automatic Stent Implant Follow-up from Intravascular OCT Pullbacks. The stents are automatically detected and their distribution is analyzed for monitoring of the stents: their malpositioning and/or tissue growth over stent struts.

Pictures

Figure 1: CFD of main coronary artery

Publications

2010
	G.Gul-Isguder, G. Unal, M. Groher, N. Navab, A.K.Kalkan, M. Degertekin, H.Hetterich, J.Rieber Manifold Learning for Image-Based Gating of Intravascular Ultrasound(IVUS) Pullback Sequences 5th International Workshop on Medical Imaging and Augmented Reality, Sep 2010, Beijing (bib)
	A. Taki, H.Hetterich, A. Roodaki, S.K. Setarehdan, G. Unal, J.Rieber, N. Navab, A. Konig A new approach for improving coronary plaque component analysis based on intravascular ultrasound images Journal of Ultrasound in Medicine and Biology., vol. 36, no. 8, pp. 1245-1258, August 2010 (bib)
	A. Taki, O. Pauly, S.K. Setarehdan, G. Unal, N. Navab IVUS-based histology of atherosclerotic plaques: improving longitudinal resolution SPIE Medical Imaging, San Diego, California, USA, 13-18 February 2010 (bib)
2009
	A. Taki, A. Roodaki, O. Pauly, S.K. Setarehdan, G. Unal, N. Navab A new method for characterization of coronary plaque composition via IVUS images IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2009), Boston, Massachusetts, USA, June 28 - July 1, 2009 (bib)

Clinical Relevance

Coronary Artery Disease (CAD) still remains the leading cause of morbidity and mortality among western countries. The appearance of CAD can range from stable angina pectoris to acute coronary syndromes (ACS), which are associated with increased mortality. Acute coronary syndromes are usually caused by acute plaque rupture, which leads to local thrombosis and occlusion of the respective coronary vessel. The localization of atherosclerotic lesions is not randomly distributed but show a characteristic pattern with preferred location at branches or bends. This results in locally different shear stress levels and flow-tissue interaction which can promote atherosclerosis.

Team

Contact Person(s)

Dr. Stefanie Demirci

Working Group

Alumni

Dr. Arash Taki

Gozde Isguder

Dr. Martin Groher

Dr. Olivier Pauly

Location

Technische Universität München Institut für Informatik / I16 Boltzmannstr. 3 85748 Garching bei München Tel.: +49 89 289-17058 Fax: +49 89 289-17059

Visit our lab at Garching.

Ludwig-Maximilians-Universität München Chirurgische Klinik und Poliklinik - Innenstadt, AG CAS Nussbaumstr. 20 80336 München Room: C2.06 Tel.: +49 89 5160-3615 Tel.: +49 89 5160-3635 Fax: +49 89 5160-3630

Visit our lab at Klinikum Innenstadt.



internal project page

Please contact Dr. Stefanie Demirci for available student projects within this research project.