A. Taki, H.Hetterich, A. Roodaki, S.K. Setarehdan, G. Unal, J.Rieber, N. Navab, A. Konig A new approach for improving coronary plaque component analysis based on intravascular ultrasound images Journal of Ultrasound in Medicine and Biology., vol. 36, no. 8, pp. 1245-1258, August 2010 (bib)
	Virtual histology (VH)-IVUS is a clinically available technique for atherosclerosis plaque characterization. It, however, suffers from a poor longitudinal resolution due to ECG-gated acquisition. This paper presents an effective algorithm for IVUS image-based histology to overcome this limitation. After plaque area extraction within an input IVUS image, a textural analysis procedure consisting of feature extraction and classification steps is proposed. The pixels of the extracted plaque area excluding the shadow region were classified into one of the three plaque components of Fibrofatty (FF), Calcification (CA) or Necrotic Core (NC) tissues. The average classification accuracy for pixel and region based validations is 75% and 87% respectively. Sensitivities (specificities) were 79% (85%) for CA, 81% (90%) for FF and 52% (82%) for NC. The kappa=0.61 and p-value=0.02 indicate good agreement of the proposed method with VH images. Finally, the enhancement in the longitudinal resolution was evaluated by reconstructing the IVUS images between the two sequential IVUS-VH images.
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