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During the analysis of single-cell time-lapse experiments of proliferating and differentiating blood stem cells, we often have to deal with two types of clumped cells. First, cells that are dividing are inherently clumped for certain time points. Second, due to the rising amount of cells over time one can observe more and more groups of clumped cells, especially in late timepoints. An additional characteristic of our data is that the experiments show cells in all differentiation states with different morphologies. |
In this project, we would like to develop a method that is able to split clumped cells, but also preserves the shape of all cell types.
You will have the opportunity to develop your project within a very interdisciplinary team, as the project will be jointly developed at the computational modeling in biology (CMB) institute at Helmholtz Zentrum and our Chair CAMP/TUM.
Diana Mateus mateus@cs.tum.edu
Carsten Marr carsten.marr@helmholtz-muenchen.de
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Title: | Segmentation of blood stem cells in bright-field images |
Abstract: | During the analysis of single-cell time-lapse experiments of proliferating and differentiating blood stem cells, we often have to deal with two types of clumped cells. First, cells that are dividing are inherently clumped for certain time points. Second, due to the rising amount of cells over time one can observe more and more groups of clumped cells, especially in late timepoints. An additional characteristic of our data is that the experiments show cells in all differentiation states with different morphologies. In this project, we would like to develop a method that is able to split clumped cells, but also preserves the shape of all cell types. |
Student: | |
Director: | Prof. Nassir Navab |
Supervisor: | Carsten Marr, Diana Mateus |
Type: | DA/MA/BA |
Area: | |
Status: | finished |
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Finish: | |
Thesis (optional): | |
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