R. Micu, T. F. Jakobs, M. Urschler, N. Navab A new registration/visualization paradigm for CT-Fluoroscopy guided RF liver ablation Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib)
	2D-3D slice-to-volume registration for abdominal organs like liver is difficult due to the breathing motion and tissue deformation. The purpose of our approach is to ease CT-fluoroscopy (CT-fluoro) based needle insertion for the Radiofrequency Liver Ablation procedure using high resolution contrasted preoperative data. In this case, low signal-to-noise ratio, absence of contrast and additional presence of needle in CT-fluoro makes it difficult to guarantee the solution of any deformable slice-to-volume registration algorithm. In this paper, we first propose a method for creating a set of ground truth (GT) simulation data based on a non-linear deformation of the CT-fluoro volume obtained from real patients. Second, we split the CT-fluoro image and apply intensity based rigid and affine registration to each section. We then propose a novel solution, which consists of intuitive visualization sequences of optimal sub-volumes of preinterventional data based on the registration results. Experiments on synthetic and real patient data and direct feedback of two interventionalists validate our alternative approach.
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