Diagnosis and treatment of the oesophageal cancer, the most rapidly increasing cancer in Western World, requires periodic examination of the tissue under endoscopic guidance together with systematic biopsies. During these examinations a flexible endoscope is inserted through the mouth of the patient into the oesophagus and biopsies (samples) are taken from suspicious regions of the tissue for pathologic investigation.
Recent developments in bio-photonics resulted in a new technology called probe-based Confocal Laser Endomicroscopy (pCLE) that enables real-time visualisation of cellular structures during the endoscopy without removing any tissue sample. A fibered confocal microprobe is introduced through the instrument channel of the endoscope to perform so called “optical biopsies”.
Although this procedure has several advantages over the conventional biopsy, it also introduces the new challenge of retargeting the optical biopsy locations in the follow-up examinations. Due to the lack of any markings such as a scar left on the tissue, re-targeting the optical biopsy locations becomes a challenge for endoscopic expert.
Recent work towards guiding the endoscopic expert in re-targeting optical biopsy sites presented very promising first step towards a complete framework for optical biopsy localisation. The aim of this project is to advance these techniques by an automatic cluster matching algorithm in order to develop a fully automatic system for optical biopsy re-targeting.
The project involves strong interaction with endoscopic experts from Klinikum Rechts der Isar.
If you are interested please send a brief CV to atasoy@in.tum.de.
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Title: | Endoscopic Cluster Matching for Optical Biopsy Localisation |
Abstract: | Diagnosis and treatment of the oesophageal cancer, the most rapidly increasing cancer in Western World, requires periodic examination of the tissue under endoscopic guidance together with systematic biopsies. During these examinations a flexible endoscope is inserted through the mouth of the patient into the oesophagus and biopsies (samples) are taken from suspicious regions of the tissue for pathologic investigation. Recent developments in bio-photonics resulted in a new technology called probe-based Confocal Laser Endomicroscopy (pCLE) that enables real-time visualisation of cellular structures during the endoscopy without removing any tissue sample. A fibered confocal microprobe is introduced through the instrument channel of the endoscope to perform so called “optical biopsies”. Although this procedure has several advantages over the conventional biopsy, it also introduces the new challenge of retargeting the optical biopsy locations in the follow-up examinations. Due to the lack of any markings such as a scar left on the tissue, re-targeting the optical biopsy locations becomes a challenge for endoscopic expert. Recent work towards guiding the endoscopic expert in re-targeting optical biopsy sites presented very promising first step towards a complete framework for optical biopsy localisation. The aim of this project is to advance these techniques by an automatic cluster matching algorithm in order to develop a fully automatic system for optical biopsy re-targeting. |
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Supervisor: | Selen Atasoy |
Type: | DA/MA/BA |
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Status: | finished |
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