WolfgangWein

Chair for Computer Aided Medical Procedures & Augmented Reality
Lehrstuhl für Informatikanwendungen in der Medizin & Augmented Reality

wolfgang.jpg Dr. Wolfgang Wein
Siemens Corporate Research
Imaging and Visualization Department
755 College Road East
08540 Princeton, New Jersey
USA

fon: +1 609 734 4477
fax: +1 609 734 3310


Research

After completing my dissertation in summer 2007, I am continuing my research in interventional imaging, particularly multimodal registration and interventional navigation, at SCR in Princeton (in close collaboration with CAMP).

Dissertation Title: Multimodal Integration of Medical Ultrasound for Treatment Planning and Interventions
Abstract:
Ultrasound is a popular, cost-effective and non-invasive medical imaging modality. If an ultrasound probe is equipped with a 3D position sensor, the acquired images can be obtained in their spatial context, a technique commonly denoted "3D freehand ultrasound".
Combining ultrasound and a pre-operative Computed Tomography (CT) scan of the same patient can be beneficial for a number of clinical applications. The core of this thesis is the development of novel methods for fully automatic alignment (i.e. registration) of 3D freehand ultrasound and CT data, based on the image content and the physical properties of both modalities.
In particular, a new method is proposed which simultaneously optimizes the linear combination of different ultrasonic effects simulated from CT, and the parameters for spatial alignment. This original concept allows local as well as global optimization of the simulation parameters, resulting in optimal registration of any modalities, where usual registration solutions do not succeed and explicit simulation of complex effects are necessary.
Furthermore, we introduce new techniques for 3D freehand ultrasound calibration and reconstruction, as well as visualization of fused CT and ultrasound data.
Two clinical applications are investigated in detail. We use a designated version of an automatic registration algorithm to integrate diagnostic ultrasound into radiation treatment planning for head and neck cancer. Our simultaneous optimization of simulation and registration is applied, in the context of treating liver and kidney metastases, for fusing CT with both diagnostic and interventional ultrasound of the abdomen. While diagnostic fusion helps doctors to assess indeterminate lesions in those organs, interventional fusion using our techniques allows for advanced image-guided navigation, in particular, for needle biopsies and radio-frequency ablations.
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Dissertation Download as PDF

Publications

W. Wein, O. Kutter, A. Aichert, D. Zikic, A. Kamen, N. Navab
Automatic non-linear mapping of pre-procedure CT volumes to 3D ultrasound
IEEE International Symposium on Biomedical Imaging (ISBI), Rotterdam, The Netherlands, April 14 - 17 2010. (bib)
W. Wein, E. Camus, M. John, M. Diallo, C. Duong, A. Al-Ahmad, R. Fahrig, A. Khamene, C. Xu
Towards Guidance of Electrophysiological Procedures with Real-time 3D Intracardiac Echocardiography Fusion to C-arm CT
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2009), London, UK, September 2009 (bib)
O. Kutter, W. Wein, N. Navab
Multi-modal registration based Ultrasound Mosaicing
Medical Image Computing and Computer-Assisted Intervention (MICCAI), London, UK, September 20-24 2009 (bib)
N. Fritz, T. Meyer, T. Blum, H.U. Lemke, M. Ilzkovitz, Y. Nevatia, M. Nolden, I. Wegner, M. Weinlich, R. Breitkreutz, W. Wein, M. Lazerges, O. Angerer, N. Navab
CAMDASS: An Augmented Reality Medical Guidance System for Spaceflights
Proceedings of Computer Assisted Radiology and Surgery (CARS 2009), Berlin, Germany, June 2009 (bib)
O. Kutter, A. Karamalis, W. Wein, N. Navab
A GPU-Based Framework for Simulation of Medical Ultrasound
SPIE Medical Imaging, Orlando, Florida, USA, February 2009 (bib)
A. Karamalis, W. Wein, O. Kutter, N. Navab
Fast Hybrid Freehand Ultrasound Volume Reconstruction
SPIE Medical Imaging, Orlando, Florida, USA, February 2009 (bib)
C. Wachinger, W. Wein, N. Navab
Registration Strategies and Similarity Measures for Three-dimensional Ultrasound Mosaicing
Journal of the University Radiologists, Academic Radiology 15 (11), pp.1404-1415. Special issue of MICCAI 2007 (bib)
W. Wein, S. Brunke, A. Khamene, M.R. Callstrom, N. Navab
Automatic CT-Ultrasound Registration for Diagnostic Imaging and Image-guided Intervention
Medical Image Analysis 12(5), pp 577-585, October 2008 (bib)
W. Wein, J.-Z. Cheng, A. Khamene
Ultrasound based Respiratory Motion Compensation in the Abdomen
MICCAI 2008 Workshop on Image Guidance and Computer Assistance for Soft-Tissue Interventions, September 10 2008, New York City, USA. (bib)
F. Bender, M. Groher, A. Khamene, W. Wein, H. Heibel, N. Navab
3D Dynamic Roadmapping for Abdominal Catheterizations
Medical Image Computing and Computer-Assisted Intervention, MICCAI, 2008, New York, USA, September 6-10 2008 (bib)
W. Wein, A. Khamene
Image-Based Method for In-Vivo Freehand Ultrasound Calibration
SPIE Medical Imaging, 16-21 February 2008, San Diego, California USA (bib)
W. Wein, A. Khamene, D.-A. Clevert, O. Kutter, N. Navab
Simulation and Fully Automatic Multimodal Registration of Medical Ultrasound
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007. Received the MICCAI 2007 Young Scientist Award. (bib)
W. Wein, M. Blume, U. Leischner, H.-U. Dodt, N. Navab
Quality-based Registration and Reconstruction of Optical Tomography Volumes
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007 (bib)
C. Wachinger, W. Wein, N. Navab
Three-Dimensional Ultrasound Mosaicing
Medical Image Computing and Computer-Assisted Intervention, MICCAI, 2007, Brisbane, Australia, October 29 - November 2 2007 (bib)
M. Blume, D. Zikic, W. Wein, N. Navab
A New and General Method for Blind Shift-Variant Deconvolution of Biomedical Images
Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007 (bib)
C. Wachinger, W. Wein, N. Navab
Ultrasound Volume Stitching
6. Jahrestagung der Deutschen Gesellschaft für Computer-und Roboter-Assistierte Chirurgie (CURAC 2007), Karlsruhe, Germany, October 2007 (bib)
W. Wein, B. Röper, N. Navab
Integrating diagnostic B-mode ultrasonography into CT-based radiation treatment planning
IEEE Transactions on Medical Imaging, 26 (June 2007), pp. 866–879 (bib)
M.S. Burns, M. Haidacher, W. Wein, I. Viola, E. Gröller
Feature Emphasis and Contextual Cutaways for Multimodal Medical Visualization
EuroVis 2007 conference, Norrköping, Sweden, May 2007 (link) (bib)
M. John, Y. Sun, S. Kadoury, W. Wein, Y. Li, J. Resnick, G. Plambeck, A. Dempsey, A. Al-Ahmad, R. Fahrig, F. Sauer
Fusion of Intracardiac Ultrasound with 3D Cardiac C-arm CT from Animal Data for Electrophysiology
Bildverarbeitung für die Medizin, Munich, Germany, March 2007 (bib)
D. Zikic, W. Wein, A. Khamene, D.-A. Clevert, N. Navab
Fast Deformable Registration of 3D-Ultrasound Using a Variational Approach
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib)
W. Wein, F. Pache, B. Röper, N. Navab
Backward-Warping Ultrasound Reconstruction for Improving Diagnostic Value and Registration
Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib)
B. Röper, W. Wein, P. Kneschaurek, M. Molls, M. Dobritz, N. Navab
Image-based fusion of diagnostic ultrasound and planning CT for radiotherapy of head and neck cancer – a way towards improvement of regional target volume delineation
12. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), May 2006, Dresden, Germany (bib)
A. Khamene, P. Bloch, W. Wein, M. Svatos, F. Sauer
Automatic Registration of Portal Images and Volumetric CT for Patient Positioning in Radiation Therapy
Medical Image Analysis 10 (2006), pages 96-112 (bib)
A. Khamene, R. Chisu, W. Wein, N. Navab, F. Sauer
A Novel Projection Based Approach for Medical Image Registration
Third International Workshop on Biomedical Image Registration (WBIR), 9-11 July 2006, Utrecht, The Netherlands. (bib)
W. Wein, B. Röper, N. Navab
Automatic Registration and Fusion of Ultrasound with CT for Radiotherapy
8th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), October 2005, Palm Springs, California USA. (bib)
W. Wein, B. Röper, N. Navab
2D/3D Registration Based on Volume Gradients
CURAC, October 2004, Munich (bib)
W. Wein, B. Röper, N. Navab
2D/3D Registration Based on Volume Gradients
SPIE Medical Imaging, 12-17 February 2005, San Diego, California USA (bib)
G. Klinker, H. Najafi, T. Sielhorst, F. Sturm, F. Echtler, M. Isik, W. Wein, C. Truebswetter
FixIt: An Approach towards Assisting Workers in Diagnosing Machine Malfunctions
Proc. of the International Workshop on Design and Engineering of Mixed Reality Systems - MIXER 2004, Funchal, Madeira, CEUR Workshop Proceedings (bib)
T. Reicher, Chr. Schwingenschlögl, W. Wein
Network Emulation for Application Development in Heterogeneous Networks
8th International Workshop on Mobile Multimedia Communications, Munich, Germany, Oct. 7, 2003. (bib)

Supervision

Teaching

Wintersemester 2004/2005

Sommersemester 2004

Wintersemester 2003/2004

Diploma Thesis

My Diploma Thesis with the title Intensity Based Rigid 2D-3D Registration Algorithms for Radiation Therapy .

Curriculum Vitae

  • 10/1999 - 01/2004: Computer science (minor physics) at Technische Universität München.
  • 02/2001 - 04/2001: Internship at the IT department of the Infineon maskhouse (MH DPT), Munich. There I evaluated the log data files of litographic mask writers for statistical process control (SPC). Due to my achievements there I have been accepted at the Infineon Student MemberChip Program .
  • 02/2002 - 04/2002: Interdisciplinary project at the new experimental nuclear reactor FRM-II in Garching (development of a framework for network based instrument control of neutron scattering experiments).
  • 07/2002 - 09/2002: Participation in the IBM Extreme Blue Summer Internship in Boeblingen. I was working in the Life Science project and developed an integrated 2D/3D chemical structure editor.
  • Since 1998 I have been working at the Baumgartner & Rath GmbH . My scope of duties comprised, among other things, customer support on site, network setup and administration, hardware configuration and programming.
  • 04/2003 - 10/2003: Internship at Siemens Corporate Research , Princeton, USA. Within the scope of my diploma thesis I was working on 2D/3D registration for patient positioning in radiation therapy.
  • From 11/2003: Ph.D. student at the new chair I16 of Prof. Nassir Navab, in collaboration with Siemens Corporate Research. Since March 2006 I'm mainly located at SCR in Princeton.

UsersForm
Title: Dr.
Firstname: Wolfgang
Middlename:  
Lastname: Wein
Picture: weinwolfgangicon.png
Birthday:  
Nationality: Germany
Languages: English, German, Bavarian
Groups: Registration/Visualization, Medical Imaging, Molecular Imaging, Computer-Aided Surgery
Expertise: Registration/Visualization, Medical Imaging, Molecular Imaging, Computer-Aided Surgery, 3D Information Presentation
Position: External Collaborator
Status: Alumni
Emailbefore: wein
Emailafter: cs.tum.edu
Room: MI 03.13.057
Telephone: +1 609 734 4477
Alumniactivity: Research Scientist at Siemens Corporate Research, Princeton NJ USA
Defensedate: 12 October 2007
Thesistitle: Multimodal Integration of Medical Ultrasound for Treatment Planning and Interventions
Alumnihomepage:  
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Personalvideotext01:  
Personalvideopreview01:  
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