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Dr. Wolfgang Wein Siemens Corporate Research Imaging and Visualization Department 755 College Road East 08540 Princeton, New Jersey USA fon: +1 609 734 4477 fax: +1 609 734 3310 |
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After completing my dissertation in summer 2007, I am continuing my research in interventional imaging, particularly multimodal registration and interventional navigation, at SCR in Princeton (in close collaboration with CAMP). Dissertation Title: Multimodal Integration of Medical Ultrasound for Treatment Planning and Interventions Abstract: Ultrasound is a popular, cost-effective and non-invasive medical imaging modality. If an ultrasound probe is equipped with a 3D position sensor, the acquired images can be obtained in their spatial context, a technique commonly denoted "3D freehand ultrasound". Combining ultrasound and a pre-operative Computed Tomography (CT) scan of the same patient can be beneficial for a number of clinical applications. The core of this thesis is the development of novel methods for fully automatic alignment (i.e. registration) of 3D freehand ultrasound and CT data, based on the image content and the physical properties of both modalities. In particular, a new method is proposed which simultaneously optimizes the linear combination of different ultrasonic effects simulated from CT, and the parameters for spatial alignment. This original concept allows local as well as global optimization of the simulation parameters, resulting in optimal registration of any modalities, where usual registration solutions do not succeed and explicit simulation of complex effects are necessary. Furthermore, we introduce new techniques for 3D freehand ultrasound calibration and reconstruction, as well as visualization of fused CT and ultrasound data. Two clinical applications are investigated in detail. We use a designated version of an automatic registration algorithm to integrate diagnostic ultrasound into radiation treatment planning for head and neck cancer. Our simultaneous optimization of simulation and registration is applied, in the context of treating liver and kidney metastases, for fusing CT with both diagnostic and interventional ultrasound of the abdomen. While diagnostic fusion helps doctors to assess indeterminate lesions in those organs, interventional fusion using our techniques allows for advanced image-guided navigation, in particular, for needle biopsies and radio-frequency ablations. |
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| Dissertation Download as PDF |
| W. Wein, O. Kutter, A. Aichert, D. Zikic, A. Kamen, N. Navab
Automatic non-linear mapping of pre-procedure CT volumes to 3D ultrasound IEEE International Symposium on Biomedical Imaging (ISBI), Rotterdam, The Netherlands, April 14 - 17 2010. (bib) |
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| W. Wein, E. Camus, M. John, M. Diallo, C. Duong, A. Al-Ahmad, R. Fahrig, A. Khamene, C. Xu
Towards Guidance of Electrophysiological Procedures with Real-time 3D Intracardiac Echocardiography Fusion to C-arm CT Medical Image Computing and Computer-Assisted Intervention (MICCAI 2009), London, UK, September 2009 (bib) |
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| O. Kutter, W. Wein, N. Navab
Multi-modal registration based Ultrasound Mosaicing Medical Image Computing and Computer-Assisted Intervention (MICCAI), London, UK, September 20-24 2009 (bib) |
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| N. Fritz, T. Meyer, T. Blum, H.U. Lemke, M. Ilzkovitz, Y. Nevatia, M. Nolden, I. Wegner, M. Weinlich, R. Breitkreutz, W. Wein, M. Lazerges, O. Angerer, N. Navab
CAMDASS: An Augmented Reality Medical Guidance System for Spaceflights Proceedings of Computer Assisted Radiology and Surgery (CARS 2009), Berlin, Germany, June 2009 (bib) |
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| O. Kutter, A. Karamalis, W. Wein, N. Navab
A GPU-Based Framework for Simulation of Medical Ultrasound SPIE Medical Imaging, Orlando, Florida, USA, February 2009 (bib) |
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| A. Karamalis, W. Wein, O. Kutter, N. Navab
Fast Hybrid Freehand Ultrasound Volume Reconstruction SPIE Medical Imaging, Orlando, Florida, USA, February 2009 (bib) |
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| C. Wachinger, W. Wein, N. Navab
Registration Strategies and Similarity Measures for Three-dimensional Ultrasound Mosaicing Journal of the University Radiologists, Academic Radiology 15 (11), pp.1404-1415. Special issue of MICCAI 2007 (bib) |
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| W. Wein, S. Brunke, A. Khamene, M.R. Callstrom, N. Navab
Automatic CT-Ultrasound Registration for Diagnostic Imaging and Image-guided Intervention Medical Image Analysis 12(5), pp 577-585, October 2008 (bib) |
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| W. Wein, J.-Z. Cheng, A. Khamene
Ultrasound based Respiratory Motion Compensation in the Abdomen MICCAI 2008 Workshop on Image Guidance and Computer Assistance for Soft-Tissue Interventions, September 10 2008, New York City, USA. (bib) |
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| F. Bender, M. Groher, A. Khamene, W. Wein, H. Heibel, N. Navab
3D Dynamic Roadmapping for Abdominal Catheterizations Medical Image Computing and Computer-Assisted Intervention, MICCAI, 2008, New York, USA, September 6-10 2008 (bib) |
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| W. Wein, A. Khamene
Image-Based Method for In-Vivo Freehand Ultrasound Calibration SPIE Medical Imaging, 16-21 February 2008, San Diego, California USA (bib) |
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| W. Wein, A. Khamene, D.-A. Clevert, O. Kutter, N. Navab
Simulation and Fully Automatic Multimodal Registration of Medical Ultrasound Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007. Received the MICCAI 2007 Young Scientist Award. (bib) |
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| W. Wein, M. Blume, U. Leischner, H.-U. Dodt, N. Navab
Quality-based Registration and Reconstruction of Optical Tomography Volumes Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007 (bib) |
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| C. Wachinger, W. Wein, N. Navab
Three-Dimensional Ultrasound Mosaicing Medical Image Computing and Computer-Assisted Intervention, MICCAI, 2007, Brisbane, Australia, October 29 - November 2 2007 (bib) |
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| M. Blume, D. Zikic, W. Wein, N. Navab
A New and General Method for Blind Shift-Variant Deconvolution of Biomedical Images Medical Image Computing and Computer-Assisted Intervention (MICCAI 2007), Brisbane, Australia, October 2007 (bib) |
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| C. Wachinger, W. Wein, N. Navab
Ultrasound Volume Stitching 6. Jahrestagung der Deutschen Gesellschaft für Computer-und Roboter-Assistierte Chirurgie (CURAC 2007), Karlsruhe, Germany, October 2007 (bib) |
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| W. Wein, B. Röper, N. Navab
Integrating diagnostic B-mode ultrasonography into CT-based radiation treatment planning IEEE Transactions on Medical Imaging, 26 (June 2007), pp. 866–879 (bib) |
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| M.S. Burns, M. Haidacher, W. Wein, I. Viola, E. Gröller
Feature Emphasis and Contextual Cutaways for Multimodal Medical Visualization EuroVis 2007 conference, Norrköping, Sweden, May 2007 (link) (bib) |
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| M. John, Y. Sun, S. Kadoury, W. Wein, Y. Li, J. Resnick, G. Plambeck, A. Dempsey, A. Al-Ahmad, R. Fahrig, F. Sauer
Fusion of Intracardiac Ultrasound with 3D Cardiac C-arm CT from Animal Data for Electrophysiology Bildverarbeitung für die Medizin, Munich, Germany, March 2007 (bib) |
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| D. Zikic, W. Wein, A. Khamene, D.-A. Clevert, N. Navab
Fast Deformable Registration of 3D-Ultrasound Using a Variational Approach Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib) |
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| W. Wein, F. Pache, B. Röper, N. Navab
Backward-Warping Ultrasound Reconstruction for Improving Diagnostic Value and Registration Proceedings of Medical Image Computing and Computer-Assisted Intervention (MICCAI 2006), Copenhagen, Denmark, October 2006 (bib) |
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| B. Röper, W. Wein, P. Kneschaurek, M. Molls, M. Dobritz, N. Navab
Image-based fusion of diagnostic ultrasound and planning CT for radiotherapy of head and neck cancer – a way towards improvement of regional target volume delineation 12. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), May 2006, Dresden, Germany (bib) |
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| A. Khamene, P. Bloch, W. Wein, M. Svatos, F. Sauer
Automatic Registration of Portal Images and Volumetric CT for Patient Positioning in Radiation Therapy Medical Image Analysis 10 (2006), pages 96-112 (bib) |
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| A. Khamene, R. Chisu, W. Wein, N. Navab, F. Sauer
A Novel Projection Based Approach for Medical Image Registration Third International Workshop on Biomedical Image Registration (WBIR), 9-11 July 2006, Utrecht, The Netherlands. (bib) |
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| W. Wein, B. Röper, N. Navab
Automatic Registration and Fusion of Ultrasound with CT for Radiotherapy 8th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), October 2005, Palm Springs, California USA. (bib) |
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| W. Wein, B. Röper, N. Navab
2D/3D Registration Based on Volume Gradients CURAC, October 2004, Munich (bib) |
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| W. Wein, B. Röper, N. Navab
2D/3D Registration Based on Volume Gradients SPIE Medical Imaging, 12-17 February 2005, San Diego, California USA (bib) |
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| G. Klinker, H. Najafi, T. Sielhorst, F. Sturm, F. Echtler, M. Isik, W. Wein, C. Truebswetter
FixIt: An Approach towards Assisting Workers in Diagnosing Machine Malfunctions Proc. of the International Workshop on Design and Engineering of Mixed Reality Systems - MIXER 2004, Funchal, Madeira, CEUR Workshop Proceedings (bib) |
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| T. Reicher, Chr. Schwingenschlögl, W. Wein
Network Emulation for Application Development in Heterogeneous Networks 8th International Workshop on Mobile Multimedia Communications, Munich, Germany, Oct. 7, 2003. (bib) |
| UsersForm | |
|---|---|
| Title: | Dr. |
| Firstname: | Wolfgang |
| Middlename: | |
| Lastname: | Wein |
| Picture: | |
| Birthday: | |
| Nationality: | Germany |
| Languages: | English, German, Bavarian |
| Groups: | Registration/Visualization, Medical Imaging, Molecular Imaging, Computer-Aided Surgery |
| Expertise: | Registration/Visualization, Medical Imaging, Molecular Imaging, Computer-Aided Surgery, 3D Information Presentation |
| Position: | External Collaborator |
| Status: | Alumni |
| Emailbefore: | wein |
| Emailafter: | cs.tum.edu |
| Room: | MI 03.13.057 |
| Telephone: | +1 609 734 4477 |
| Alumniactivity: | Research Scientist at Siemens Corporate Research, Princeton NJ USA |
| Defensedate: | 12 October 2007 |
| Thesistitle: | Multimodal Integration of Medical Ultrasound for Treatment Planning and Interventions |
| Alumnihomepage: | |
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